Who should we be offering pharmacological Thrombo-prophylaxis to following below knee lower limb immobilisation?
Author: Dr Matthew Reay
Type: MLP-research
Date: June 2022
Abstract:
Lower limb immobilisation increases the risk of Venous Thrombo-Embolism (VTE). The aim of this medical literature project is to firstly examine the risk factors most associated with an increased risk of VTE and the accuracy of risk stratification scores in predicting who will benefit from thrombo-prophylaxis. There are a number of risk stratifications scores available, all with varying accuracy. The TRiP (cast score) shows the most promise with 2 prospective trials (CASTING and TILLIRI) currently running, with results yet to be published.
The ideal risk stratification score, will have low rates of both under (sensitivity) and over treatment (specificity).