Urgent Bite 141 – Opioids and serotonin syndrome
Important we consider potential interactions between opioids and antidepressants.
Novavax Medsafe alert
Today (Thursday 8 September) Medsafe published a safety alert in relation to the COVID-19 Novavax (Nuvaxovid) vaccine: Myocarditis and pericarditis have been reported with Nuvaxovid (Novavax COVID-19 Vaccine) There have been a small number of cases of myocarditis and pericarditis reported internationally following vaccination with Nuvaxovid. The medicine sponsor now considers that myocarditis and pericarditis…
Who should we be offering pharmacological Thrombo-prophylaxis to following below knee lower limb immobilisation?
Author: Dr Matthew Reay
Type: MLP-research
Date: June 2022
Abstract:
Lower limb immobilisation increases the risk of Venous Thrombo-Embolism (VTE). The aim of this medical literature project is to firstly examine the risk factors most associated with an increased risk of VTE and the accuracy of risk stratification scores in predicting who will benefit from thrombo-prophylaxis. There are a number of risk stratifications scores available, all with varying accuracy. The TRiP (cast score) shows the most promise with 2 prospective trials (CASTING and TILLIRI) currently running, with results yet to be published.
The ideal risk stratification score, will have low rates of both under (sensitivity) and over treatment (specificity).
Diverticulitis: the role of antibiotics in urgent care
Author: Dr Eleri Clissold
Type: MLP-research
Date: April 2022
Abstract:
Our understanding of this common and painful disease is evolving. What was thought to be a predominantly infective process is postulated to be inflammatory and self-limiting in the majority of cases. Over several decades multiple high quality studies have emerged questioning the role of antibiotics in the management of acute diverticulitis without perforation, sepsis or other complications. No study has demonstrated the superiority of any antibiotic strategy in any one of multiple outcomes assessed. This literature search seeks to examine the evidence in-depth and place it in context for urgent care practitioners.
Urgent Bite 140 – The Gilula Arcs (and lunate dislocation)
An important eponym that may help us miss fewer lunate dislocations on initial presentation.